Tag Archives: Eli Lilly

The next dose

I was rudely awakened by something that suddenly hit me. You see, nothing in life is free, it is almost a given certainty, even the rising of the sun now comes at a price as we see it. So my brain woke up by the image I show you below

So, here we see that President Trump nullified its America contribution of 988 million dollars, but that money doesn’t come for free. I get that and I believe that the ‘hidden’ revenue is out in the open now. Consider that the World Health Organisation is ‘heralding’ the following “The World Health Organization (WHO) promotes comprehensive national medicines policies to ensure safe, quality, and affordable medication use. The “Medication Without Harm” initiative aims to reduce severe, avoidable medication-related harm by 50% globally, focusing on high-risk situations, polypharmacy, and transitions of care.” I am willing to bet the house that American pharmacies is pushing some rules to keep in business, as such it would be prudent that all these contracts are now null and void. President Trump opened that door. I am willing to be that Indian pharmacies are roaring to fill that place as such they would be starting a tremendous 2026. 

Now lets be clear, this is pure speculation and I reckon that the White House will be shouting that these ‘donations’ were just that ‘donations’, but the world is a lot more complex and the thread unravelled will open up all ready seeking partners is revenue and America seemingly closed that door yesterday. Now we need to know and to find out what the 988 million dollars enable America to rely on and close that off, the media is no use here as they are mostly under control by American stakeholders. And they are suddenly worried that they have to reside in other corners now. The pharmacies who were ‘enjoying’ this speculative advantage is losing that advantage. They relied on the status quo and president Trump obliterated that. And as I see it, The World Health Organization (WHO) Model List of Essential Medicines (EML) contains over 350+ safe, effective, and cost-effective medicines for priority health conditions, the question is who is pushing these 350+ names, so what is involved? Those who create that list will have some order of importance as to the ‘origin’ of that medication, it is updated every two years to guide national health systems. The list, including the EMLc for children, covers essential drugs like antibiotics, painkillers, and vaccines, with the 2025 update focusing on diabetes and cancer care. But what makes that list? I am asking as I do not know and how many generic Indian pharmacies are involved? It is the largest nightmare for American pharmacies. So as some are ‘hammering’ the ‘policies to ensure safe, quality, and affordable medication use’ but President Trump just blew away that setting, as such the Indian pharmacies now get a way in. What a lovely setting the White House allowed for. As such I foresee that Johnson & Johnson, Eli Lilly, AbbVie, Pfizer,  Merck & Co, Amgen, Gilead Sciences, and Bristol Myers Squibb are facing (a few) grey days now, perhaps not all of them, but some of them will and it is hard on the settings they now face as they are short in donations, about $988,000,000 short. And who exactly decides on “Medication Without Harm”? What are the foundational markers that make it medication without harm?
So this is pure speculation, but the easiest option is the greed track, it tends to go in foretelling ways and the foretelling way of greed is the easiest to read and to predict. But it also comes with the setting that I might easily be wrong. It is all set that America over the years have made demands for the $988,000,000 they are currently paying. If my premise is wrong, so is the viewpoint that I am creating here. So take care with accepting this point of view, because it is speculative and might be easily disproven, the question is, will it and is my point of view wrong? And if (a big if) I am right what will the American Pharmacies in 2026, 2027 and 2028 face? And if that is set, what more revenue will America be forced out of?

Have a great day today, time to see where the diner is coming from (answer: Rice and beads, with Salmon and hot sauce from my kitchen).

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Mental health or Medication

We have seen the premise in a few stages in the last decade and for the most people lean towards one or the other and that is fine, it is a hard choice to make and there is no real evidence which of the two is better in the long run. Mental health needs treatment, medication is at times not a cure, merely a way to create a timeline for treatment, or to minimise the impact of the situation. Yet there is also a medial state that is not mental health based, for example treating people with cystic fibrosis who have two copies of the F508del mutation, for them there is Orkambi. Yet, what is the status when this involves a politician? How delusional is a public speaker allowed to become before he is considered unhealthy and unable to perform his function?

That question came up when the Guardian gave me ‘Labour pledges to break patents and offer latest drugs on NHS‘ (at https://www.theguardian.com/politics/2019/sep/24/labour-pledges-to-break-patents-and-offer-latest-drugs-on-nhs). So not only is he making claims, he is basically pronouncing war on the World Trade Organisation, abolishing the TRIPS agreement and throwing it all overboard. As we realise that the World Health Organisation gives us: “As of February 2005, 148 countries are Members of the WTO. In becoming Members of the WTO, countries undertake to adhere to the 18 specific agreements annexed to the Agreement establishing the WTO. They cannot choose to be party to some agreements but not others“, the UK and the EU are both signatories, so Jeremy Corbyn is stupid enough to set a stage of war that endangers millions. To give a little consideration to the metrics, we get the numbers on Cystic Fibrosis, not merely those with these two mutations (a specific subset), we see that more than 70,000 people worldwide are living with cystic fibrosis. Approximately 1,000 new cases of CF are diagnosed each year. More than 75 percent of people with CF are diagnosed by age 2. More than half of the CF population is age 18 or older. Now this is not a good thing, we admit, yet we are looking to a population that is less than 0.001% of the entire population, more important the people that need Orkambi are a mere subset of that. And for the UK it would linearly mean that it affects only 0.1% of the 0.001% that optionally have it. That is his ‘limelight’; can someone please kick this idiot out of the Labour party (preferably out of UK politics altogether)?

And in the second part, no political party has any business being in the pharmaceutical industry, there is a reason why industrials should never have any political power (well, we lost that one ages ago, but still). His voice giving us: ‘party will create company to make cheap versions of drugs‘, whilst the metrics give us that it will be a population less than a 100 that have this version of Cystic Fibrosis that is what he is fighting for? He cannot even properly represent his constituency and now he is starting patent wars as well as a war with the World Trade Organisation on abolishing or severely changing The Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS)? Not only does it not make sense, the impact could be devastating for the UK. This is a person screaming ‘election’ and then spinning silent when it was offered.

It is my personal view that UK labour is better off getting the clown Ronald McDonald to do the Labour party bidding, and it will do a better job than Jeremy Corbyn ever could. His promises are no longer empty, they are now right-out dangerous.

Pharmaceuticals

There is a larger pharmaceutical issue and it has been going on for well over a decade, the issue that patents are reapplied well over 30 years after date, often in a slightly changed form, only barely passing the innovation line is the largest concern for generic medication, yet there are dozens of examples and Orkambi is nowhere near the top 10 in this. Lyrica (Pfizer), Rituxan (roche), Cialis (Eli Lilly), Xolair (Roche/Novartis), Restatis (Allergan) are 5 of the top 10 expiring patents with a value of a little over $16 billion in total, and those owners would like a little longer exclusivity, because the expiration will hit their bottom line in a real hard way. In that list Orkambi does not even stack up to any decent degree and we have larger issues gaining patents with a generic option and Corbyn’s need to make war with TRIPS, whilst the NHS has larger issues, especially as it was Labour who botched the NHS IT project losing £11 billion and small change to the degree of several millions is not one who should be casting voices on ending patents.

The sentiment is not wrong, but the chosen field is a little beyond stupid, making us wonder whether the man is personally dealing with mental health issues. We all have had that moment where we wanted to stand in front of Dwayne Johnson calling him Tinkerbell, not really wise, but we all have those inflated moments of self, to do what Jeremy Corbyn does worse hiding behind one 9 year old with: “Luis is denied the medicine he needs because its American manufacturer refuses to sell the drug to the NHS for an affordable price“, so this is not some Cystic Fibrosis case, this is a very specific case and the medication required many millions to create and pass FDA approval. A medication for CF patients with a rare mutation. With two specific mutations in a disease that knows more than 1,700 mutations that had been found in the CFTR gene. Orkambi works for patients with the F508del mutation in both copies the CFTR gene, the most common mutation in people with cystic fibrosis worldwide. So even if it is the most common, there are 1700 mutations meaning that his war on one medication to a specific subset that comes down to a lot less than 100 patients in the UK. So this idiot (read: Jeremy Corbyn) goes to war, promising to abolish TRIPS and leaving the WTO, all for a subset of people, too small to fill a village? Now consider that the UK has Pharmaceutical interests as well, the top two players in the UK are GlaxoSmithKline and AstraZeneca representing almost £132 billion pounds, because if he does what he does, then those two will vacate as well, this is how stupid Jeremy Corbyn is, but he is hoping that you will not notice this as he is in feigned tears for one nine year old child. I only mentioned the top two, the field is larger than that, but Jeremy Corbyn is willing to throw it all in the air.

Can you please explain to me how the government budget will be met when two companies representing a taxable £100,000,000,000 leave the UK? This is the kind of short-sighted, BS carrying ventures that Jeremy Corbyn is handing its constituents. His claim is ‘In England about 5,000 young patients could benefit, but the NHS said it could not afford to pay the bill‘, if there are worldwide 70,000 Cystic Fibrosis (CF) patients the UK cannot have that many, the claim of “US drugs company Vertex priced Orkambi at over £100,000 per patient per year” might be true and for 100 patients that is still serious money, but we need to recognise that we cannot hand every working person a Ferrari, we do not have the money, and it is that extreme. We are in a position where until a patent ends, the maker gets to set the price, or not sell the product. In light of the numbers I see, I want Jeremy Corbyn to give us an exact list of these 5,000 patients and what medication they need. I reckon that the picture shifts a lot faster at that point. And we agree that larger changes are required, yet making a direct case to the WTO that patents cannot be extended above the 35 years is a lot better than abolishing the WTO. Yet Jeremy Corbyn has no options to do that, so he comes with a delusional plan to start a company that ‘create company to make cheap versions of drugs‘, whilst there are plenty of companies doing that, the case remains that patents hand exclusivity until they expire, this year 26 drugs are facing patent expiration and yet, Orkambi is not among them, but 26 patents will become generic, before 2022 42 patents will expire and that is good for a lot of people, yet this system is already in place, we do not need some delusional politician to add his need to become a rich pharmaceutical cat as well.

To be honest, I have never had such a low regard of UK Labour ever before, the fact that I have twice the regard towards LibDems than towards Labour at present is something I never thought possible in the age of Ed Miliband, whomever thought that Corbyn would be a worthy successor deserved the title ‘Joker of the Year‘, as I personally see it, it is actually that bad at present.

So whomever is happy that this optional mental health case is running the UK labour party is in desperate need of some medication (generic NHS funded options will be available).

 

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